May 25, 2012
Local engineers take on blood plasma fractionation projectBack
PIETERMARITZBURG|Pietermaritzburg-based|Anderson Engineering|Democratic Republic Of Congo|Israel|Kenya|Nigeria|Seychelles|South Africa|Tunisia|Zambia|National Bioproducts Institute|Clean-in-place Equipment|Equipment Manufacturer|Medical And Pharmaceutical Engineering|Pharmaceutical Hygiene Perspective|Pharmaceuticals|Stainless Steel|Stainless Steel Processing Equipment Manufacturer|Steel|Sterility|David Stubbings|Hans Coertse
© Reuse this
Preliminary discussions between the two parties began in 2007 and, in 2010, the project started gaining momentum. This is the biggest turnkey project ever undertaken by Anderson Engineering, says managing member Hans Coertse, who believes the plant to be one-of-a-kind in the country.
Anderson Engineering put together the designs for a range of equipment to meet the NBI’s stringent specifications. The project came with significant physical constraints and the equipment had to be designed accordingly.
“The NBI had an existing building it wanted the project to work in and there was no additional space available, so it was quite a challenge,” he notes.
The equipment manufacturer also designed the equipment to cope with extreme temperatures, ranging from –30 °C to 122 °C, which are needed for the processing method and to achieve sterility – a key aspect from a pharmaceutical hygiene perspective.
“In the process design, we had to ensure that everything was hygienically designed and executed accordingly,” he adds.
The insides of the vessels had to be mirror-polished, which is achieved by using various grades of polishing materials. “This leads to the highest possible level of hygiene,” he says. “If you continue polishing the surface with finer and finer grades of materials, it becomes a mirror polish. But this is only necessary in extreme circumstances – which this was.” The total surface area of mirror polishing required on the vessel internal surfaces was 158 m2.
The upgraded fractionation facility comprises clean-in-place equipment custom-designed to fit into one of the smaller areas within the facility, as well as a main process room with four 6 500 ℓ fractionation vessels, a 2 000 ℓ dissolution vessel, a buffer dispensing system and control panels, which can be accessed by means of an upper level platform.
The facility also includes a control room, which is separated from the main process room by a glass viewing window. The utilities and glycol chilling plant, which has a 5 000 ℓ capacity, are installed on the level above the process room as these function under the normal ventilation conditions in that area.
Anderson used stainless steel and granite in the control area to achieve the standard of hygiene levels required in the fractionation facility.
Further, the company had to work synergistically with air conditioning, refrigeration, electrical and control systems specialists contracted to complement the Anderson Engineering team.
This project also marked Anderson Engineering’s first complete adherence to the International Society for Pharmaceutical Engineering’s Good Automated Manufacturing Practice guidelines, established in 1994, to ensure that pharmaceuticals companies worldwide adhere to standard operating procedures, ensuring the high standards of quality expected in the industry.
The processing method requires absolute control over four critical parameters, namely alcohol concentration, temperature, pH level and ionic strength, to extract and purify therapeutic proteins in plasma.
Because of the sensitivity of the project, which required comprehensive needs analyses and several revisions of the scope of work, the NBI was very particular when choosing a company to meet its requirements
Ultimately, Anderson Engineering was chosen based on its capacity and compliance. “We took into account the quality of Anderson’s workmanship, its experience in the pharmaceuticals and food industries, as well as its references,” says NBI CEO David Stubbings.
Because of some logistical hold-ups at the end of the installation phase, which extended the process, the commissioning phase only began early this year, and is progressing well, says Coertse. “We are very near the completion of the water trial phase and, within a few weeks, the NBI intends to go into full-scale production.”
Coertse says there has always been healthy competition in this sector of the industry, but believes the company has a competitive advantage in terms of its process design capability and the turnkey packages it delivers.
He is also optimistic about the future of the company, which has seen positive growth in the last four years, which coincided with a significant increase in capacity during this time. The company expanded its staff complement from about 60 to 80 employees over that timeframe.
“Our growth has been natural and [was determined] by need. We probably have occupied our premises to the fullest extent,” Coertse says, adding that the company is comfortable with where it stands at present and does not intend to expand anytime soon.
Anderson Engineering has specific and detailed technology and quality control systems in place so as not to compromise the company’s high standards. “One of the aspects we concentrate on is getting our quality right and keeping it right,” says Coertse.
The Pietermaritzburg-based company has a presence across South Africa and further afield in Nigeria, Kenya, the Democratic Republic of Congo, the Seychelles, Tunisia, Zambia and Israel.
Edited by: Chanel de Bruyn© Reuse this Comment Guidelines
Other Science & Technology News
Recent Research Reports
This Week's Magazine
The Electronic Systems Laboratory (ESL) of the Department of Electrical and Electronic Engineering at Stellenbosch University is strongly reaffirming its position as one of South Africa’s leading centres for satellite technology and expertise. It is currently...
The world’s lowest-cost diesel-electric locomotive is not made in China, but in Pretoria, at RRL Grindrod Locomotives’ newly upgraded 30 000 m2 plant. The company’s locomotive pricing is “more competitive than any other original-equipment manufacturer (OEM)...
The South African Defence Review 2012, released to the public at the end of last month (despite the year given in its title) recommends the creation of the post of Chief Defence Scientist. This official would be responsible for the management of defence technology...
AltX-listed engineering technology company Ansys has been awarded an R188-million contract by Transnet to supply integrated dashboard display systems to the freight rail utility’s locomotives. Black-owned and controlled Ansys developed the bespoke integrated system...
South Africa’s sole nuclear power station Koeberg, which is located in the Western Cape, breached a major operations milestone on April 4, which marked the thirtieth anniversary of Unit 1 having been connected to the grid. Eskom, which operates the two-unit plant,...