http://www.engineeringnews.co.za
  SEARCH
Login
R/€ = 13.88Change: 0.04
R/$ = 12.68Change: 0.01
Au 1085.07 $/ozChange: -6.38
Pt 947.00 $/ozChange: -19.00
 
 
Note: Search is limited to the most recent 250 articles. Set date range to access earlier articles.
Where? With... When?








Start
 
End
 
 
And must exclude these words...
Close Main Search
Close Main Login
My Profile News Alerts Newsletters Logout Close Main Profile
 
Agriculture   Automotive   Chemicals   Competition Policy   Construction   Defence   Economy   Electricity   Energy   Environment   ICT   Metals   Mining   Science and Technology   Services   Trade   Transport & Logistics   Water  
What's On Press Office Tenders Suppliers Directory Research Jobs Announcements Letters Contact Us
 
 
 
RSS Feed
Article   Comments   Other News   Research   Magazine  
 
 
May 25, 2012

Local engineers take on blood plasma fractionation project

Back
Engineering|PIETERMARITZBURG|Pietermaritzburg-based|Africa|Anderson Engineering|Building|Components|Design|Installation|PROJECT|Stainless Steel|System|Systems|Water|Africa|Democratic Republic Of Congo|Israel|Kenya|Nigeria|Seychelles|South Africa|Tunisia|Zambia|National Bioproducts Institute|Clean-in-place Equipment|Equipment|Equipment Manufacturer|Manufacturing|Medical And Pharmaceutical Engineering|Pharmaceutical Hygiene Perspective|Pharmaceuticals|Products|Solutions|Stainless Steel|Stainless Steel Processing Equipment Manufacturer|Steel|Systems|Sterility|David Stubbings|Hans Coertse|Water
Engineering||Africa|Building|Components|Design|Installation|PROJECT|Stainless Steel|System|Systems|Water|Africa|Democratic Republic Of Congo|Kenya|Zambia||Equipment|Manufacturing|Products|Solutions|Steel|Systems||Water
engineering|pietermaritzburg|pietermaritzburg-based|africa-company|anderson-engineering|building|components|design|installation|project|stainless-steel-company|system|systems-company|water-company|africa|democratic-republic-of-congo|israel|kenya|nigeria|seychelles|south-africa|tunisia|zambia|national-bioproducts-institute|clean-in-place-equipment|equipment|equipment-manufacturer|manufacturing|medical-and-pharmaceutical-engineering|pharmaceutical-hygiene-perspective|pharmaceuticals|products|solutions|stainless-steel|stainless-steel-processing-equipment-manufacturer|steel|systems|sterility|david-stubbings|hans-coertse|water
© Reuse this



Custom design specialist and stainless steel processing equipment manufacturer Anderson Engineering has completed the upgrade of a unique blood plasma fractionation facility for nongovernmental organisation the National Bioproducts Institute (NBI) and says the project has pushed the boundaries of medical and pharmaceutical engineering in South Africa.

Preliminary discussions between the two parties began in 2007 and, in 2010, the project started gaining momentum. This is the biggest turnkey project ever undertaken by Anderson Engineering, says managing member Hans Coertse, who believes the plant to be one-of-a-kind in the country.

Anderson Engineering put together the designs for a range of equipment to meet the NBI’s stringent specifications. The project came with significant physical constraints and the equipment had to be designed accordingly.

“The NBI had an existing building it wanted the project to work in and there was no additional space available, so it was quite a challenge,” he notes.

The equipment manufacturer also designed the equipment to cope with extreme temperatures, ranging from –30 °C to 122 °C, which are needed for the processing method and to achieve sterility – a key aspect from a pharmaceutical hygiene perspective.

“In the process design, we had to ensure that everything was hygienically designed and executed accordingly,” he adds.

The insides of the vessels had to be mirror-polished, which is achieved by using various grades of polishing materials. “This leads to the highest possible level of hygiene,” he says. “If you continue polishing the surface with finer and finer grades of materials, it becomes a mirror polish. But this is only necessary in extreme circumstances – which this was.” The total surface area of mirror polishing required on the vessel internal surfaces was 158 m2.

The upgraded fractionation facility comprises clean-in-place equipment custom-designed to fit into one of the smaller areas within the facility, as well as a main process room with four 6 500 ℓ fractionation vessels, a 2 000 ℓ dissolution vessel, a buffer dispensing system and control panels, which can be accessed by means of an upper level platform.

The facility also includes a control room, which is separated from the main process room by a glass viewing window. The utilities and glycol chilling plant, which has a 5 000capacity, are installed on the level above the process room as these function under the normal ventilation conditions in that area.

Anderson used stainless steel and granite in the control area to achieve the standard of hygiene levels required in the fractionation facility.

Further, the company had to work synergistically with air conditioning, refrigeration, electrical and control systems specialists contracted to complement the Anderson Engineering team.

This project also marked Anderson Engineering’s first complete adherence to the International Society for Pharmaceutical Engineering’s Good Automated Manufacturing Practice guidelines, established in 1994, to ensure that pharmaceuticals companies worldwide adhere to standard operating procedures, ensuring the high standards of quality expected in the industry.


The fractionation process involves separating the various components of blood plasma to manufacture pharmaceutical products, such as human albumin (water soluble protein) solutions, human immuno- globulin (antibody) preparations and human coagulation (clotting) factor proteins.

The processing method requires absolute control over four critical parameters, namely alcohol concentration, temperature, pH level and ionic strength, to extract and purify therapeutic proteins in plasma.

Because of the sensitivity of the project, which required comprehensive needs analyses and several revisions of the scope of work, the NBI was very particular when choosing a company to meet its requirements

Ultimately, Anderson Engineering was chosen based on its capacity and compliance. “We took into account the quality of Anderson’s workmanship, its experience in the pharmaceuticals and food industries, as well as its references,” says NBI CEO David Stubbings.


The design phase of the project began in May 2008 and Anderson started with project orders in 2009. The equipment delivery was scheduled for March 2010 and installation was completed by the end of May 2011.

Because of some logistical hold-ups at the end of the installation phase, which extended the process, the commissioning phase only began early this year, and is progressing well, says Coertse. “We are very near the completion of the water trial phase and, within a few weeks, the NBI intends to go into full-scale production.”


Anderson Engineering specialises in the design and manufacture of stainless steel processing equipment, which is why two of its key markets are the food and pharmaceuticals industries, which require hygienic, specialised designs.

Coertse says there has always been healthy competition in this sector of the industry, but believes the company has a competitive advantage in terms of its process design capability and the turnkey packages it delivers.

He is also optimistic about the future of the company, which has seen positive growth in the last four years, which coincided with a significant increase in capacity during this time. The company expanded its staff complement from about 60 to 80 employees over that timeframe.

“Our growth has been natural and [was determined] by need. We probably have occupied our premises to the fullest extent,” Coertse says, adding that the company is comfortable with where it stands at present and does not intend to expand anytime soon.

Anderson Engineering has specific and detailed technology and quality control systems in place so as not to compromise the company’s high standards. “One of the aspects we concentrate on is getting our quality right and keeping it right,” says Coertse.

The Pietermaritzburg-based company has a presence across South Africa and further afield in Nigeria, Kenya, the Democratic Republic of Congo, the Seychelles, Tunisia, Zambia and Israel.

Edited by: Chanel de Bruyn
Creamer Media Senior Deputy Editor Online
© Reuse this Comment Guidelines (150 word limit)
 
 
 
 
 
 
 
 
Other Medical and Pharmaceutical Engineering News
CURE, TREATMENT OR VACCINATION? Combining HIV cure, treatment and vaccination research could lead to developing an effective solution to combating the pandemic
The combined research into human immunodeficiency virus (HIV) treatments, therapies and vaccinations could provide the answers to combating the deadly virus. This was the message conveyed at an HIV colloquium held at the Sci-Bono Discovery Centre in Newtown,...
HOSPITAL ENGINEERING A industry best practice norms and standards are being developed for built environment professionals working in the healthcare sector
Healthcare infrastructure norms and standards developer Infrastructure Unit Support Systems (IUSS) is in the process of developing and publishing a set of healthcare infrastructure standards and norms, to act as a built environment best practice guideline. The IUSS...
CONTAMINENT FREE ZONE ISO cleanrooms are used to ensure that contaminants do not interfere with material research or the equipment being manufactured
South African mineral research organisation Mintek launched a R13-million manufacturing facility last month to produce lateral-flow diagnostics test strips for infectious diseases such as malaria, the human immunodeficiency virus (HIV) and tuberculosis (TB). The...
More
 
 
Latest News
Updated 2 hours 15 minutes ago This eight-page brief is a synopsis of key developments in the electricity industry over the past 12 months, including details of South Africa’s constrained power system; State-owned power utility Eskom’s financial status and tariffs, capacity expansion programme,...
The Department of Labour (DoL) will on Tuesday start hosting a series of national public hearings to review the farming and forestry sectors’ minimum wages and conditions of employment as prescribed in Sectoral Determination (SD) 13. The department explained in a...
The Independent Communications Authority of South Africa (Icasa) on Monday announced that it was “eager” to “reinitiate” the licensing process for the assignment of the high-demand spectrum. Icasa, which was responsible for the allocation of spectrum to broadcasting...
More
 
 
Recent Research Reports
Real Economy Year Book 2015 (PDF Report)
There are very few beacons of hope on South Africa’s economic horizon. Economic growth is weak, unemployment is rising, electricity supply is insufficient to meet demand and/or spur growth, with poor prospects for many of the commodities mined and exported. However,...
Real Economy Insight: Automotive 2015 (PDF Report)
Creamer Media’s Real Economy Year Book comprises separate reports under the banner Real Economy Insight and investigates key developments in the automotive, construction, electricity, road and rail, steel, water, gold, iron-ore and platinum sectors.
Real Economy Insight: Water 2015 (PDF Report)
Creamer Media’s Real Economy Year Book has been divided into individual reports under the banner Real Economy Insight and investigates key developments in the automotive, construction, electricity, road and rail, steel, water, coal, gold, iron-ore and platinum sectors.
Real Economy Insight: Construction 2015 (PDF Report)
Creamer Media’s Real Economy Year Book has been divided into individual reports under the banner Real Economy Insight and investigates key developments in the automotive, construction, electricity, road and rail, steel, water, coal, gold, iron-ore and platinum sectors.
Real Economy Insight: Electricity 2015 (PDF Report)
Creamer Media’s Real Economy Year Book has been divided into individual reports under the banner Real Economy Insight and investigates key developments in the automotive, construction, electricity, road and rail, steel, water, coal, gold, iron-ore and platinum sectors.
Real Economy Insight: Road and Rail 2015 (PDF Report)
Creamer Media’s Real Economy Year Book has been divided into individual reports under the banner Real Economy Insight and investigates key developments in the automotive, construction, electricity, road and rail, steel, water, coal, gold, iron-ore and platinum sectors.
 
 
 
 
 
This Week's Magazine
Daimler truck test engineer Dirk Stranz pushes one button, and then retracts his hands from the steering wheel of the Mercedes-Benz Future Truck 2025. “And now the truck is driving itself.”
The statutory body responsible for skills development and support in the banking sector, BANKSETA, was investing R68-million in the capacity building project of the University of Venda (UniVen), announced Bankseta company secretary Caroline King at a media event in...
LIONEL MOYAL Cloud services providers must compete against other cloud services providers for business by providing up-to-date systems and services
Legacy information technology (IT) systems are becoming increasingly obsolete because of the maturity, efficiencies and cost effectiveness of cloud-based IT services, says information and communication technology major T-Systems subsidiary Intervate head Lionel...
ARMANDÉ KRUGER Balancing the collection and processing of data must be aligned to strategy
Many complementary services enable companies to derive broad value from data inside and outside them. The complexity of data management means that companies’ strategies determine the various data systems and functions they will use, says PBT Group regional sales...
The South African Civil Aviation Authority (SACAA) has announced that it had awarded the country’s first remotely piloted aircraft systems (RPAS) pilot’s licence. It was issued on Friday, July 10, to SACAA employee and qualified commercial pilot Nicole Swart,...
 
 
 
 
 
 
 
 
 
Alert Close
Embed Code Close
content
Research Reports Close
Research Reports are a product of the
Research Channel Africa. Reports can be bought individually or you can gain full access to all reports as part of a Research Channel Africa subscription.
Find Out More Buy Report
 
 
Close
Engineering News
Completely Re-Engineered
Experience it now. Click here
*website to launch in a few weeks
Subscribe Now for $96 Close
Subscribe Now for $96